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Kim De Keersmaecker Selected Research

MRK 560

1/2021PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia.

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Kim De Keersmaecker Research Topics

Disease

20Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
04/2022 - 06/2005
18Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL)
11/2021 - 06/2005
13Neoplasms (Cancer)
01/2022 - 04/2008
11Leukemia
04/2022 - 06/2011
2Carcinogenesis
01/2021 - 02/2015
2Breast Neoplasms (Breast Cancer)
01/2021 - 02/2017
2Multiple Myeloma
01/2020 - 01/2017
2Genetic Translocation (Chromosomal Translocation)
10/2011 - 07/2008
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
06/2011 - 06/2005
1Diamond-Blackfan Anemia (Anemia, Diamond Blackfan)
01/2022
1Congenital Bone Marrow Failure Syndromes
01/2022
1Hyperplasia
01/2021
1Weight Loss (Weight Reduction)
01/2021
1Reticulocytosis
01/2020
1Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders)
01/2019
1Lymphoma (Lymphomas)
01/2019
1Splenomegaly
01/2019
1Mitochondrial Diseases (Mitochondrial Disease)
01/2019
1T-Cell Leukemia (Leukemia, T Cell)
11/2010

Drug/Important Bio-Agent (IBA)

9Ribosomal Proteins (Ribosomal Protein)IBA
01/2022 - 02/2015
6Transcription Factors (Transcription Factor)IBA
01/2017 - 08/2010
5Proteins (Proteins, Gene)FDA Link
01/2022 - 02/2013
5Imatinib Mesylate (Gleevec)FDA Link
01/2021 - 06/2005
4Phosphotransferases (Kinase)IBA
11/2021 - 06/2005
3Serine (L-Serine)FDA Link
01/2021 - 11/2019
3Glycine (Aminoacetic Acid)FDA LinkGeneric
01/2021 - 11/2019
3Pharmaceutical PreparationsIBA
01/2021 - 01/2014
3Dexamethasone (Maxidex)FDA LinkGeneric
11/2020 - 04/2008
2DNA (Deoxyribonucleic Acid)IBA
04/2022 - 11/2021
2ruxolitinibIBA
01/2021 - 12/2019
2EltanexorIBA
01/2021 - 11/2020
2Gamma Secretase Inhibitors and ModulatorsIBA
01/2021 - 04/2008
2Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2021 - 04/2008
2Vincristine (Oncovin)FDA LinkGeneric
11/2020 - 04/2008
2RNA (Ribonucleic Acid)IBA
11/2019 - 01/2013
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2014 - 07/2008
1NucleotidesIBA
04/2022
1Thimerosal (Thiomersal)IBA
01/2021
1MRK 560IBA
01/2021
1Sertraline (Zoloft)FDA LinkGeneric
01/2021
1Transfer RNA (tRNA)IBA
01/2021
1Antidepressive Agents (Antidepressants)IBA
01/2021
1deoxyguanosine triphosphate (dGTP)IBA
12/2020
1forodesineIBA
12/2020
1Doxorubicin (Adriamycin)FDA LinkGeneric
11/2020
1carfilzomibIBA
01/2020
1Ribosomal DNA (rDNA)IBA
01/2020
1Messenger RNA (mRNA)IBA
11/2019
1Adenosine Triphosphate (ATP)IBA
01/2019
1Complement Factor B (Factor B)IBA
01/2019
1venetoclaxIBA
01/2019
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2019
1DNA-Directed RNA Polymerases (RNA Polymerase)IBA
10/2017
1Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (p56 lck)IBA
01/2014
1bosutinibIBA
01/2014
1Dasatinib (BMS 354825)FDA Link
01/2014
1src-Family KinasesIBA
01/2014
1tyrosine receptor (receptor, tyrosine)IBA
05/2012
1Phosphoric Monoester Hydrolases (Phosphatases)IBA
05/2012
1Protein Isoforms (Isoforms)IBA
04/2012
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
04/2012
1Phosphatidylinositols (Phosphatidylinositol)IBA
04/2012
1Polycomb Repressive Complex 2IBA
02/2012
1Homeodomain Proteins (Proteins, Homeobox)IBA
11/2010
1RNA-Binding Proteins (RNA-Binding Protein)IBA
08/2010
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
08/2010
1CytokinesIBA
06/2010
1Protein Tyrosine PhosphatasesIBA
06/2010
1Nuclear Pore Complex Proteins (Nucleoporins)IBA
07/2008
1GlucocorticoidsIBA
04/2008
1Therapeutic UsesIBA
04/2008

Therapy/Procedure

7Therapeutics
10/2018 - 06/2011
3Drug Therapy (Chemotherapy)
01/2021 - 04/2008
1Precision Medicine
12/2020